Simulated MRI with JEMRIS
We plan to use the JEMRIS simulator as starting point in the openGTN project to generate realistic simulated MRI of the brain, spine and heart, including anatomy, function and pathology:
Detailed information about JEMRIS can be found in this publication:
T. Stoecker et al., High-performance computing MRI simulations, Magn Reson Med 64:186–193 (2010)
and the software can be downloaded from the JEMRIS website.
Details on the foreseen application of JEMRIS in the openGTN project can be found here. The European Society of Magnetic Resonance in Medicine and Biology (ESMRMB) organizes a course on the use of JEMRIS once every 2 years (next edition foreseen for 2019).
An example of the successful application of JEMRIS to generate realistic simulated MRI data of the carotid arteries can be found in this publication:
Harm A. Nieuwstadt et al., Numerical Simulations of Carotid MRI Quantify the Accuracy in Measuring Atherosclerotic Plaque Components In Vivo, Magn Reson Med 72:188–201 (2014).
In this paper, we describe how we successfully used JEMRIS to generate very realistic simulated carotid MR images with ground truth plaque segmentations, and used these to assess the accuracy of manual plaque component segmentation. The included plaque components were: lipid-rich necrotic core (LRNC) and fibrous cap (FC).
The figure below show a comparison between real and simulated MRI for the same plaque geometry and composition. It can be seen that the intensity patterns along the line A, B, C, D, E are very similar.
As soon as we have simulated MRI available, a link to the database with this data will be made public, with an explanation of how to access that data. The database will contain simulated MR images of the brain, spine and the heart as well as the ground truth anatomical models used to generate these data.